Cancun is famous for its nightlife, and several of the big resort hotels in the Hotel Zone have discos. Some also host Mexican fiesta nights that include dinner and a folkloric show. Among the popular hot spots are El Azucar next to the Dreams Cancun and—known for their loud music and large, rowdy crowds—Coco Bongo, Dady'O, and the biggest disco in Cancun, The City, on Boulevard Kukulcan.
You also can take the fiesta to the water on one of Cancun's "party cruises." Back on land, if you tire of the party scene, try the jazz club Roots, in Ciudad Cancun. It's a nice alternative to the disco beat of clubs along Boulevard Kukulcan.
Most bars stay open until at least 2 am, and discos until at least 3 am. Many places keep going until dawn, especially when spring-break revelers are in town.